Host autophagy mediates organ wasting and nutrient mobilization for tumor growth.

ABSTRACT: During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through transfer of amino acids. Here we uncover a third critical role of autophagy in mediating systemic organ wasting and nutrient mobilization for tumor growth using a well-characterized malignant tumor model in Drosophila melanogaster. Micro-computed X-ray tomography and metabolic profiling reveal that Ras^V12 ; scrib^-/- tumors grow 10-fold in volume, while systemic organ wasting unfolds with progressive muscle atrophy, loss of body mass, -motility, -feeding, and eventually deat

SUBMITTER: Khezri R 

PROVIDER: S-EPMC8441431 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature