Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males.

ABSTRACT:

Objective

To examine the factors associated with increased deoxyribonucleic acid fragmentation index (DFI), evaluate the pregnancy outcomes of men with increased DFI, and compare three independent DFI assays.

Design

Secondary analysis.

Setting

Nine US-based fertility centers.

Patients

Infertile men (N = 147) with sperm concentration ≤15 × 10⁶/mL, motility ≤40%, or normal morphology ≤4% were enrolled. The female partners were ovulatory, ≤40 years old, and had documented tubal patency.

Interventions

At a baseline visit, the men provided a semen sample. The couples attempted conception without assistance for 3 months and with ovarian stimulation and intrauterine insemination in the subsequent 3 months.

Main outcome measures

The DFI was ana

SUBMITTER: Rios JS 

PROVIDER: S-EPMC8441563 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature