Does timing matter when initiating elagolix in a natural menstrual cycle?

ABSTRACT:

Objective

To investigate the efficacy of elagolix when administered at different time points in a menstrual cycle.

Design

Clinical case series.

Setting

Academic reproductive endocrinology center.

Patients

Ovulatory women not desiring pregnancy.

Interventions

Six doses of elagolix 200 mg were administered over 4 days, starting at 3 different points in a menstrual cycle: early follicular; late follicular; and midluteal. Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) concentrations were measured at baseline, during elagolix administration, and 1 day after the last dose. Transvaginal ultrasounds were performed to monitor follicle sizes.

Main outcome measures

Serum FSH, LH, E2, and P.

Results

SUBMITTER: Danis RB 

PROVIDER: S-EPMC8441568 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature