Lower functional connectivity of white matter during rest and working memory tasks is associated with cognitive impairments in schizophrenia.

ABSTRACT:

Background

Schizophrenia can be understood as a disturbance of functional connections within brain networks. However, functional alterations that involve white matter (WM) specifically, or their cognitive correlates, have seldomly been investigated, especially during tasks.

Methods

Resting state and task fMRI images were acquired on 84 patients and 67 controls. Functional connectivities (FC) between 46 WM bundles and 82 cortical regions were compared between the groups under two conditions (i.e., resting state and during working memory retention period). The FC density of each WM bundle was then compared between groups. Associations of FC with cognitive scores were evaluated.

Results

FC measures were lower in schizophrenia relative to controls for external capsule, ci

SUBMITTER: Gao Y 

PROVIDER: S-EPMC8442250 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature