Diversity of developing peripheral glia revealed by single-cell RNA sequencing.

ABSTRACT: The peripheral nervous system responds to a wide variety of sensory stimuli, a process that requires great neuronal diversity. These diverse neurons are closely associated with glial cells originating from the neural crest. However, the molecular nature and diversity among peripheral glia are not understood. Here, we used single-cell RNA sequencing to profile developing and mature glia from somatosensory dorsal root ganglia and auditory spiral ganglia. We found that glial precursors (GPs) in these two systems differ in their transcriptional profiles. Despite their unique features, somatosensory and auditory GPs undergo convergent differentiation to generate molecularly uniform myelinating and non-myelinating Schwann cells. By contrast, somatosensory and auditory satellite glial cells retai

SUBMITTER: Tasdemir-Yilmaz OE 

PROVIDER: S-EPMC8442251 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature