Systematic analysis of the relationship between ovarian cancer prognosis and alternative splicing.

ABSTRACT:

Background

Ovarian cancer(OC) is the gynecological tumor with the highest mortality rate, effective biomarkers are of great significance in improving its prognosis. In recent years, there have been many studies on alternative splicing (AS) events, and the role of AS events in tumor has become a focus of attention.

Methods

Data were downloaded from the TCGA database and Univariate Cox regression analysis was performed to determine AS events associated with OC prognosis.Eight prognostic models of OC were constructed in R package, and the accuracy of the models were evaluated by the time-dependent receiver operating characteristic (ROC) curves.Eight types of survival curves were drawn to evaluate the differences between the high and low risk groups.Independent prognostic factor

SUBMITTER: Zhang D 

PROVIDER: S-EPMC8442315 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature