Co-expression and prognosis analyses of GLUT1-4 and RB1 in breast cancer.

ABSTRACT:

Background

Current treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively poor. It has been reported that glucose transporter 1 (GLUT1) is overexpressed in breast cancer cells; however, its association with the prognosis is mostly unclear. Moreover, retinoblastoma gene 1 (RB1) might be used as a biomarker for the sensitivity of breast cancer cells to GLUT1 inhibitors, which brought us to the hypothesis that there might be a close correlation between the expression of GLUT1-4 and the expression of RB1.

Methods

In this study, we systematically analyzed the co-expression of GLUT1-4 and the influence of GLUT1-4 gene expression on the prognosis of breast cancer using data mining methods. We also explored

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8442321 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature