Quantitative muscle MRI as a sensitive marker of early muscle pathology in myotonic dystrophy type 1.

ABSTRACT:

Background

Quantitative muscle MRI as a sensitive marker of early muscle pathology and disease progression in adult-onset myotonic dystrophy type 1. The utility of muscle MRI as a marker of muscle pathology and disease progression in adult-onset myotonic dystrophy type 1 (DM1) was evaluated.

Methods

This prospective, longitudinal study included 67 observations from 36 DM1 patients (50% female), and 92 observations from 49 healthy adults (49% female). Lower-leg 3T magnetic resonance imaging (MRI) scans were acquired. Volume and fat fraction (FF) were estimated using a three-point Dixon method, and T2-relaxometry was determined using a multi-echo spin-echo sequence. Muscles were segmented automatically. Mixed linear models were conducted to determine group differences across m

SUBMITTER: van der Plas E 

PROVIDER: S-EPMC8442354 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature