Construction and investigation of a circRNA-associated ceRNA regulatory network in Tetralogy of Fallot.

ABSTRACT:

Background

As the most frequent type of cyanotic congenital heart disease (CHD), tetralogy of Fallot (TOF) has a relatively poor prognosis without corrective surgery. Circular RNAs (circRNAs) represent a novel class of endogenous noncoding RNAs that regulate target gene expression posttranscriptionally in heart development. Here, we investigated the potential role of the ceRNA network in the pathogenesis of TOF.

Methods

To identify circRNA expression profiles in TOF, microarrays were used to screen the differentially expressed circRNAs between 3 TOF and 3 control human myocardial tissue samples. Then, a dysregulated circRNA-associated ceRNA network was constructed using the established multistep screening strategy.

Results

In summary, a total of 276 differentially exp

SUBMITTER: Yu H 

PROVIDER: S-EPMC8442392 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature