Mapping the evolving landscape of super-enhancers during cell differentiation.

ABSTRACT:

Background

Super-enhancers are clusters of enhancer elements that play critical roles in the maintenance of cell identity. Current investigations on super-enhancers are centered on the established ones in static cell types. How super-enhancers are established during cell differentiation remains obscure.

Results

Here, by developing an unbiased approach to systematically analyze the evolving landscape of super-enhancers during cell differentiation in multiple lineages, we discover a general trend where super-enhancers emerge through three distinct temporal patterns: conserved, temporally hierarchical, and de novo. The three types of super-enhancers differ further in association patterns in target gene expression, functional enrichment, and 3D chromatin organization, suggesting

SUBMITTER: Kai Y 

PROVIDER: S-EPMC8442463 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature