Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1.

ABSTRACT: Glycation, the term for non-enzymatic covalent reactions between aldehyde metabolites and nucleophiles on biopolymers, results in deleterious cellular damage and diseases. Since Parkinsonism-associated protein DJ-1 was proposed as a novel deglycase that directly repairs glycated adducts, it has been considered a major contributor to glycation damage repair. Recently, an interesting debate over the mechanism of glycation repair by DJ-1 has emerged, focusing on whether the substrate of DJ-1 is glycated adducts or the free small aldehydes. The physiological significance of DJ-1 on glycation defense also remains in question. This debate is complicated by the fact that glycated biomolecular adducts are in rapid equilibrium with free aldehydes. Here, we summarize experimental evidence for the tw

SUBMITTER: Jun YW 

PROVIDER: S-EPMC8442549 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature