Relationships between preoperative cortical thickness, postoperative electroencephalogram slowing, and postoperative delirium.

ABSTRACT:

Background

It is unclear how preoperative neurodegeneration and postoperative changes in EEG delta power relate to postoperative delirium severity. We sought to understand the relative relationships between neurodegeneration and delta power as predictors of delirium severity.

Methods

We undertook a prospective cohort study of high-risk surgical patients (>65 yr old) to identify predictors of peak delirium severity (Delirium Rating Scale-98) with twice-daily delirium assessments (NCT03124303). Participants (n=86) underwent preoperative MRI; 54 had both an MRI and a postoperative EEG. Cortical thickness was calculated from the MRI and delta power from the EEG.

Results

In a linear regression model, the interaction between delirium status and preoperative mean cortical th

SUBMITTER: White MF 

PROVIDER: S-EPMC8442560 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature