Manifold dynamic non-covalent interactions for steering molecular assembly and cyclization.

ABSTRACT: Deciphering rich non-covalent interactions that govern many chemical and biological processes is crucial for the design of drugs and controlling molecular assemblies and their chemical transformations. However, real-space characterization of these weak interactions in complex molecular architectures at the single bond level has been a longstanding challenge. Here, we employed bond-resolved scanning probe microscopy combined with an exhaustive structural search algorithm and quantum chemistry calculations to elucidate multiple non-covalent interactions that control the cohesive molecular clustering of well-designed precursor molecules and their chemical reactions. The presence of two flexible bromo-triphenyl moieties in the precursor leads to the assembly of distinct non-planar dimer and tr

SUBMITTER: Song S 

PROVIDER: S-EPMC8442717 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature