Stereodivergent synthesis of β-iodoenol carbamates with CO₂ via photocatalysis.

ABSTRACT: Photocatalytic conversion of carbon dioxide (CO₂) into value-added chemicals is of great significance from the viewpoint of green chemistry and sustainable development. Here, we report a stereodivergent synthesis of β-iodoenol carbamates through a photocatalytic three-component coupling of ethynylbenziodoxolones, CO₂ and amines. By choosing appropriate photocatalysts, both Z- and E-isomers of β-iodoenol carbamates, which are difficult to prepare using existing methods, can be obtained stereoselectively. This transformation featured mild conditions, excellent functional group compatibility and broad substrate scope. The potential synthetic utility of this protocol was demonstrated by late-stage modification of bioactive molecules and pharmaceuticals as we

SUBMITTER: Wang L 

PROVIDER: S-EPMC8442729 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature