Megasphaera in the Stool Microbiota Is Negatively Associated With Diarrheal Cryptosporidiosis.

ABSTRACT:

Background

The protozoan parasites in the Cryptosporidium genus cause both acute diarrheal disease and subclinical (ie, nondiarrheal) disease. It is unclear if the microbiota can influence the manifestation of diarrhea during a Cryptosporidium infection.

Methods

To characterize the role of the gut microbiota in diarrheal cryptosporidiosis, the microbiome composition of both diarrheal and surveillance Cryptosporidium-positive fecal samples from 72 infants was evaluated using 16S ribosomal RNA gene sequencing. Additionally, the microbiome composition prior to infection was examined to test whether a preexisting microbiome profile could influence the Cryptosporidium infection phenotype.

Results

Fecal microbiome composition was associated with diarrheal symptoms at 2 time

SUBMITTER: Carey MA 

PROVIDER: S-EPMC8442784 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature