Resistance to Mycobacterium tuberculosis Infection Among Household Contacts: A Multinational Study.

ABSTRACT:

Background

Some contacts of patients with tuberculosis remain negative on tests for tuberculosis infection, despite prolonged exposure, suggesting they might be resistant to Mycobacterium tuberculosis infection. The objective of this multinational study was to estimate the proportion of household contacts resistant to M. tuberculosis (resisters).

Methods

We conducted a longitudinal study enrolling index patients enrolled in treatment for pulmonary multidrug- or rifampin-resistant tuberculosis and their household contacts. Contacts were tested for tuberculosis infection with a tuberculin skin test (TST) and interferon-gamma release assay (IGRA) at baseline and after 1 year. Exposure was quantified based on index patients' infectiousness, index patient and household contact in

SUBMITTER: Baliashvili D 

PROVIDER: S-EPMC8442792 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature