PRIME-IPD SERIES Part 1. The PRIME-IPD tool promoted verification and standardization of study datasets retrieved for IPD meta-analysis.

ABSTRACT:

Objectives

We describe a systematic approach to preparing data in the conduct of Individual Participant Data (IPD) analysis.

Study design and setting

A guidance paper proposing methods for preparing individual participant data for meta-analysis from multiple study sources, developed by consultation of relevant guidance and experts in IPD. We present an example of how these steps were applied in checking data for our own IPD meta analysis (IPD-MA).

Results

We propose five steps of Processing, Replication, Imputation, Merging, and Evaluation to prepare individual participant data for meta-analysis (PRIME-IPD). Using our own IPD-MA as an exemplar, we found that this approach identified missing variables and potential inconsistencies in the data, facilitated the standardi

SUBMITTER: Dewidar O 

PROVIDER: S-EPMC8442853 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature