Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo.
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ABSTRACT:
SUBMITTER: Shahini A
PROVIDER: S-EPMC8442867 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo.
Shahini Aref A Rajabian Nika N Choudhury Debanik D Shahini Shahryar S Vydiam Kalyan K Nguyen Thy T Kulczyk Joseph J Santarelli Tyler T Ikhapoh Izuagie I Zhang Yali Y Wang Jianmin J Liu Song S Stablewski Aimee A Thiyagarajan Ramkumar R Seldeen Kenneth K Troen Bruce R BR Peirick Jennifer J Lei Pedro P Andreadis Stelios T ST
Science advances 20210903 36
Senescence of myogenic progenitors impedes skeletal muscle regeneration. Here, we show that overexpression of the transcription factor NANOG in senescent myoblasts can overcome the effects of cellular senescence and confer a youthful phenotype to senescent cells. NANOG ameliorated primary hallmarks of cellular senescence including genomic instability, loss of proteostasis, and mitochondrial dysfunction. The rejuvenating effects of NANOG included restoration of DNA damage response via up-regulati ...[more]
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