INTS11 regulates hematopoiesis by promoting PRC2 function.
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ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC8442872 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
INTS11 regulates hematopoiesis by promoting PRC2 function.
Zhang Peng P Sui Pinpin P Chen Shi S Guo Ying Y Li Ying Y Ge Guo G Ge Guo G Zhu Ganqian G Yang Hui H Rogers Cody M CM Sung Patrick P Nimer Stephen D SD Xu Mingjiang M Yang Feng-Chun FC
Science advances 20210901 36
INTS11, the catalytic subunit of the Integrator (INT) complex, is crucial for the biogenesis of small nuclear RNAs and enhancer RNAs. However, the role of INTS11 in hematopoietic stem and progenitor cell (HSPC) biology is unknown. Here, we report that INTS11 is required for normal hematopoiesis and hematopoietic-specific genetic deletion of <i>Ints11</i> leads to cell cycle arrest and impairment of fetal and adult HSPCs. We identified a novel INTS11-interacting protein complex, Polycomb repressi ...[more]
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