High-salt diet mediates interplay between NK cells and gut microbiota to induce potent tumor immunity.
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ABSTRACT:
SUBMITTER: Rizvi ZA
PROVIDER: S-EPMC8442882 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
High-salt diet mediates interplay between NK cells and gut microbiota to induce potent tumor immunity.
Rizvi Zaigham Abbas ZA Dalal Rajdeep R Sadhu Srikanth S Kumar Yashwant Y Kumar Shakti S Gupta Sonu Kumar SK Tripathy Manas Ranjan MR Rathore Deepak Kumar DK Awasthi Amit A
Science advances 20210910 37
High-salt diet (HSD) modulates effector and regulatory T cell functions and promotes tissue inflammation in autoimmune diseases. However, effects of HSD and its association with gut microbiota in tumor immunity remain undefined. Here, we report that HSD induces natural killer (NK) cell–mediated tumor immunity by inhibiting PD-1 expression while enhancing IFNγ and serum hippurate. Salt enhanced tumor immunity when combined with a suboptimal dose of anti-PD1 antibody. While HSD-induced tumor immun ...[more]
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