Interdependence of a mechanosensitive anion channel and glutamate receptors in distal wound signaling.

ABSTRACT: Glutamate has dual roles in metabolism and signaling; thus, signaling functions must be isolatable and distinct from metabolic fluctuations, as seen in low-glutamate domains at synapses. In plants, wounding triggers electrical and calcium (Ca²⁺) signaling, which involve homologs of mammalian glutamate receptors. The hydraulic dispersal and squeeze-cell hypotheses implicate pressure as a key component of systemic signaling. Here, we identify the stretch-activated anion channel MSL10 as necessary for proper wound-induced electrical and Ca²⁺ signaling. Wound gene induction, genetics, and Ca²⁺ imaging indicate that MSL10 acts in the same pathway as the glutamate receptor–like proteins (GLRs). Analogous to mammalian NMDA glutamate receptors, GLRs may serve as co

SUBMITTER: Moe-Lange J 

PROVIDER: S-EPMC8442888 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature