Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens.
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ABSTRACT:
SUBMITTER: Monteith AJ
PROVIDER: S-EPMC8442908 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens.
Monteith Andrew J AJ Miller Jeanette M JM Maxwell C Noel CN Chazin Walter J WJ Skaar Eric P EP
Science advances 20210910 37
Neutrophils and macrophages are critical to the innate immune response, but cooperative mechanisms used by these cells to combat extracellular pathogens are not well understood. This study reveals that S100A9-deficient neutrophils produce higher levels of mitochondrial superoxide in response to <i>Staphylococcus aureus</i> and, as a result, form neutrophil extracellular traps (suicidal NETosis). Increased suicidal NETosis does not improve neutrophil killing of <i>S. aureus</i> in isolation but a ...[more]
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