Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney.
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ABSTRACT:
SUBMITTER: Pace JA
PROVIDER: S-EPMC8442927 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney.
Pace Jesse A JA Bronstein Robert R Guo Yiqing Y Yang Yaqi Y Estrada Chelsea C CC Gujarati Nehaben N Salant David J DJ Haley John J Bialkowska Agnieszka B AB Yang Vincent W VW He John C JC Mallipattu Sandeep K SK
Science advances 20210903 36
Podocyte loss triggering aberrant activation and proliferation of parietal epithelial cells (PECs) is a central pathogenic event in proliferative glomerulopathies. Podocyte-specific Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor, is essential for maintaining podocyte homeostasis and PEC quiescence. Using mice with podocyte-specific knockdown of Klf4, we conducted glomerular RNA-sequencing, tandem mass spectrometry, and single-nucleus RNA-sequencing to identify cell-specific tra ...[more]
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