Continuous and automated slug flow nanoextraction for rapid partition coefficient measurement.

ABSTRACT: Octanol-water partition coefficients (log K_ow) are widely used in pharmaceutical and environmental chemistry to assess the lipophilicity of compounds. Traditionally log K_ow is determined using a shake-flask method that uses milliliters of sample and solvent and requires hours for preparation, extraction, and analysis. Here, we report an automated system for rapid log K_ow determination for an array of compounds using slug flow nanoextraction (SFNE) enabled by a microfluidic chip. In the method, an autosampler is used to introduce 1 μL of sample into a microfluidic device that segments the injected volume into a series of 4 nL slugs that are each paired to an adjacent octanol slug. Each octanol-water phase pair is compartmentalized by an

SUBMITTER: Payne EM 

PROVIDER: S-EPMC8442929 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature