Nanoscale molecular architecture controls calcium diffusion and ER replenishment in dendritic spines.
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ABSTRACT:
SUBMITTER: Basnayake K
PROVIDER: S-EPMC8443180 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Nanoscale molecular architecture controls calcium diffusion and ER replenishment in dendritic spines.
Basnayake Kanishka K Mazaud David D Kushnireva Lilia L Bemelmans Alexis A Rouach Nathalie N Korkotian Eduard E Holcman David D
Science advances 20210915 38
Dendritic spines are critical components of neuronal synapses as they receive and transform synaptic inputs into a succession of calcium-regulated biochemical events. The spine apparatus (SA), an extension of smooth endoplasmic reticulum, regulates slow and fast calcium dynamics in spines. Calcium release events deplete SA calcium ion reservoir rapidly, yet the next cycle of signaling requires its replenishment. How spines achieve this replenishment without triggering calcium release remains unc ...[more]
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