Characterization of Ferromagnetic Composite Implants for Tumor Bed Hyperthermia.

ABSTRACT: Hyperthermia therapy (HT) is becoming a well-recognized method for the treatment of cancer when combined with radiation or chemotherapy. There are many ways to heat a tumor and the optimum approach depends on the treatment site. This study investigates a composite ferromagnetic surgical implant inserted in a tumor bed for the delivery of local HT. Heating of the implant is achieved by inductively coupling energy from an external magnetic field of sub-megahertz frequency. Implants are formed by mechanically filling a resected tumor bed with self-polymerizing plastic mass mixed with small ferromagnetic thermoseeds. Model implants were manufactured and then heated in a 35 cm diameter induction coil of our own design. Experimental results showed that implants were easily heated to temperatures

SUBMITTER: Osintsev AM 

PROVIDER: S-EPMC8443243 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature