Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder.

ABSTRACT:

Background

Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear.

Methods

A total of 40 medication-free patients with OCD and 38 HCs underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Data were analyzed with the degree approach and a support vector machine (SVM) classifier.

Results

Patients with OCD showed increased degree values in the left thalamus and left cerebellum Crus I and decreased degree values in the left dorsolateral prefrontal cortex, right precuneus, and left postcentral gyrus. SVM classification analysis indicated that

SUBMITTER: Lv D 

PROVIDER: S-EPMC8443365 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature