Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes.

ABSTRACT: Mechanisms underlying anxiety disorders remain elusive despite the discovery of several associated genes. We constructed the protein-protein interaction networks (interactomes) of six anxiety disorders and noted enrichment for striatal expression among common genes in the interactomes. Five of these interactomes shared distinctive overlaps with the interactomes of genes that were differentially expressed in two striatal compartments (striosomes and matrix). Generalized anxiety disorder and social anxiety disorder interactomes showed exclusive and statistically significant overlaps with the striosome and matrix interactomes, respectively. Systematic gene expression analysis with the anxiety disorder interactomes constrained to contain only those genes that were shared with striatal compartm

SUBMITTER: Karunakaran KB 

PROVIDER: S-EPMC8443595 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature