Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer.

ABSTRACT: Transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator, Kelch-like ECH associated protein 1 (Keap1), are at the interface between redox and intermediary metabolism. Nrf2 activation is protective in models of human disease and has benefits in clinical trials. Consequently, the Keap1/Nrf2 protein complex is a drug target. However, in cancer Nrf2 plays a dual role, raising concerns that Nrf2 activators may promote growth of early neoplasms. To address this concern, we examined the role of Nrf2 in development of colorectal adenomas by employing genetic, pharmacological, and metabolomic approaches. We found that colorectal adenomas that form in Gstp^-/-: Apc^Min/+ mice are characterized by altered one-carbon metabolism and

SUBMITTER: Knatko EV 

PROVIDER: S-EPMC8443638 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature