Role of myeloid cell leptin signaling in the regulation of glucose metabolism.

ABSTRACT: Although innate immunity is linked to metabolic health, the effect of leptin signaling in cells from the innate immune system on glucose homeostasis has not been thoroughly investigated. We generated two mouse models using Cre-lox methodology to determine the effect of myeloid cell-specific leptin receptor (Lepr) reconstitution and Lepr knockdown on in vivo glucose metabolism. Male mice with myeloid cell-specific Lepr reconstitution (Lyz2Cre⁺Lepr^loxTB/loxTB) had better glycemic control as they aged compared to male mice with whole-body transcriptional blockade of Lepr (Lyz2Cre^-Lepr^loxTB/loxTB). In contrast, Lyz2Cre⁺Lepr^loxTB/loxTB females only had a trend for diminished hyperglycemia after a prolonged fast. During glucose to

SUBMITTER: Pereira S 

PROVIDER: S-EPMC8443652 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature