An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells.

ABSTRACT: Refractory T cell acute leukaemias that no longer respond to treatment would benefit from new modalities that target T cell-specific surface proteins. T cell associated surface proteins (the surfaceome) offer possible therapy targets to reduce tumour burden but also target the leukaemia-initiating cells from which tumours recur. Recent studies of the T cell leukaemia surfaceome confirmed that CD7 is highly expressed in overt disease. We have used an anti-CD7 antibody drug conjugate (ADC) to show that the binding of antibody to surface CD7 protein results in rapid internalization of the antigen together with the ADC. As a consequence, cell killing was observed via induction of apoptosis and was dependent on cell surface CD7. The in vitro cytotoxic activity (EC₅₀) of the anti-CD7

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8443841 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature