Inhaled prostacyclin analogues in COVID-19 associated acute respiratory distress syndrome: scientific rationale.

ABSTRACT:

Background

COVID-19 associated acute respiratory distress syndrome (CARDS) is a severe form of SARS CoV-2 infection and affects about 15-30% of hospitalized patients with a high mortality rate. Growing research and data suggest several available drugs with appropriate pharmacological effects to treat COVID-19.

Main body

Prostacyclin analogues are regiments for pulmonary artery hypertension. Prostacyclin analogues are expected to be beneficial in treating CARDS based on at least four rationales: (1) inhaled prostacyclin analogues improve oxygenation, V/Q mismatch, and act as an ARDS therapy alternative; (2) it alleviates direct SARS-CoV-2-related coagulopathy; (3) increases nitric oxide production; and (4) possible anti-inflammatory effect. Prostacyclin analogues are availabl

SUBMITTER: Mulia EPB 

PROVIDER: S-EPMC8443914 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature