Interaction between gender and post resuscitation interventions on neurological outcome in an asphyxial rat model of cardiac arrest.

ABSTRACT:

Purpose

Previous clinical studies have suggested an effect of gender on outcome after out-of-hospital cardiac arrest, but the results are conflicting and there is no uniform agreement regarding gender differences in survival and prognosis. The present study was aimed to investigate the interaction between gender and post resuscitation interventions on neurological outcome in an asphyxial rat model of cardiac arrest.

Methods

Asphyxia was induced by blocking the endotracheal tube in 120 adult Sprague-Dawley rats (60 males and 60 females) at the same age. Cardiopulmonary resuscitation (CPR) was started after 5 min of untreated cardiac arrest. Animals were randomized into one of the three post resuscitation care intervention groups (n = 40, 20 males) immediately after resuscitat

SUBMITTER: Wang J 

PROVIDER: S-EPMC8443961 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature