Genetic testing in women with early-onset breast cancer: a Traceback pilot study.

ABSTRACT:

Purpose

In Sweden, a Traceback approach, i.e., a retrospective genetic outreach activity, among cancer patients is not normally used in clinical practice. In this pilot study, we wanted to evaluate a Traceback strategy for possible future clinical implementation and investigate why not all women with early-onset breast cancer underwent genetic testing when they were first diagnosed.

Methods

Out of all women (n = 409) diagnosed with breast cancer at ≤ 35 years in Southern Sweden between 2000 and 2017, 63 had not previously been tested. These women were offered an analysis of the genes BRCA1, BRCA2, PALB2, CHEK2, and ATM through a standardized letter. Subsequently, women with normal test results were informed through a letter and carriers of pathogenic variants were contacted

SUBMITTER: Augustinsson A 

PROVIDER: S-EPMC8443966 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature