Incidence of completed suicide and suicide attempts in a global prospective study of Huntington's disease.

ABSTRACT:

Background

Risk of death from suicide in Huntington's disease is notably elevated relative to that in the general population, although the incidence within HD populations has not been precisely defined. Robust incidence estimates of suicidal behavior can serve as references for HD therapeutic research and post-marketing surveillance to help evaluate the suicidality risk of novel therapeutics.

Aims

To estimate the incidence rate of completed suicide and suicide attempt in the global, prospective HD cohort study Enroll-HD that records these events per protocol.

Method

A total of 20 912 participants were available for analysis (HD gene-expansion carriers (HDGECs) n = 15 924; non-HDGECs n = 4988) representing a collective observation period of 53 390 participant-years. Ea

SUBMITTER: van Duijn E 

PROVIDER: S-EPMC8444051 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature