Association of Hypothyroidism and Clinical Depression: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Hypothyroidism is considered a cause of or a strong risk factor for depression, but recent studies provide conflicting evidence regarding the existence and the extent of the association. It is also unclear whether the link is largely due to subsyndromal depression or holds true for clinical depression.

Objective

To estimate the association of hypothyroidism and clinical depression in the general population.

Data sources

PubMed, PsycINFO, and Embase databases were searched from inception until May 2020 for studies on the association of hypothyroidism and clinical depression.

Study selection

Two reviewers independently selected epidemiologic and population-based studies that provided laboratory or International Statistical Classification of Diseases an

SUBMITTER: Bode H 

PROVIDER: S-EPMC8444067 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature