Mapping lung ventilation through stress maps derived from biomechanical models of the lung.

ABSTRACT:

Purpose

Most existing computed tomography (CT)-ventilation imaging techniques are based on deformable image registration (DIR) of different respiratory phases of a four-dimensonal CT (4DCT) scan of the lung, followed by the quantification of local breathing-induced changes in Hounsfield Units (HU) or volume. To date, only moderate correlations have been reported between these CT-ventilation metrics and standard ventilation imaging modalities for adaptive lung radiation therapy. This study evaluates the use of stress maps derived from biomechanical model-based DIR as an alternative CT-ventilation metric.

Materials and methods

Six patients treated for lung cancer with conventional radiation therapy were retrospectively analyzed. For each patient, a 4DCT scan and Tc-99m SPECT-V

SUBMITTER: Cazoulat G 

PROVIDER: S-EPMC8444226 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature