Falls: a marker of preclinical Alzheimer disease: a cohort study protocol.

ABSTRACT:

Introduction

Progression to symptomatic Alzheimer disease (AD) occurs slowly over a series of preclinical stages. Declining functional mobility may be an early indicator of loss of brain network integration and may lead to an increased risk of experiencing falls. It is unknown whether measures of functional mobility and falls are preclinical markers of AD. The purpose of this study is to examine (1) the relationship between falls and functional mobility with AD biomarkers to determine when falls occur within the temporal progression to symptomatic Alzheimer disease, and (2) the attentional compared with perceptual/motor systems that underlie falls and functional mobility changes seen with AD.

Methods and analysis

This longitudinal cohort study will be conducted at the Knight

SUBMITTER: Bollinger RM 

PROVIDER: S-EPMC8444237 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature