Low ADAMTS-13 predicts adverse outcomes in hospitalized patients with suspected heparin-induced thrombocytopenia.

ABSTRACT:

Background

Heparin-induced thrombocytopenia (HIT) is a life-threatening thrombotic complication after heparin exposure. However, the role of ADAMTS-13 and von Willebrand factor (VWF) in the disease process and outcomes of HIT is not known.

Objective

To determine the potential role of ADAMTS-13 and VWF in hospitalized patients suspected with HIT.

Methods

Associations of the HIT tests, ADAMTS-13 activity, and VWF antigen or activity with other clinical parameters and outcomes in the patients suspected with HIT were determined.

Results

Of 261 patients, 87 (33.3%) were positive and 174 (66.7%) were negative for a HIT antibody determined by an enzyme immunoassay (EIA). Of these 87 EIA+ patients, 31 (35.6%) were also positive but 56 (64.4%) were negative for serotoni

SUBMITTER: Chan M 

PROVIDER: S-EPMC8444283 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature