1α,25-dihydroxyvitamin D₃ protects retinal ganglion cells in glaucomatous mice.

ABSTRACT:

Background

Glaucoma is an optic neuropathy characterized by loss of function and death of retinal ganglion cells (RGCs), leading to irreversible vision loss. Neuroinflammation is recognized as one of the causes of glaucoma, and currently no treatment is addressing this mechanism. We aimed to investigate the anti-inflammatory and neuroprotective effects of 1,25(OH)₂D₃ (1α,25-dihydroxyvitamin D₃, calcitriol), in a genetic model of age-related glaucomatous neurodegeneration (DBA/2J mice).

Methods

DBA/2J mice were randomized to 1,25(OH)₂D₃ or vehicle treatment groups. Pattern electroretinogram, flash electroretinogram, and intraocular pressure were recorded weekly. Immunostaining for RBPMS, Iba-1, and GFAP was carried out on

SUBMITTER: Lazzara F 

PROVIDER: S-EPMC8444391 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature