Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.

ABSTRACT:

Background and purpose

Neuromyelitis optica spectrum disorder (NMOSD) is mainly an anti-aquaporin 4 (anti-AQP4) autoantibodies-mediated idiopathic inflammatory demyelinating disease of the central nervous system. Systemic and local inflammatory responses play a key role in the pathophysiology of NMOSD. However, the role of the crucial immunomodulators CD4⁺CD25⁺ forkhead box P3⁺ (Foxp3) regulatory T cells (Tregs) has not been investigated in NMOSD.

Methods

Twenty-five patients with anti-AQP4-postive NMOSD undergoing an attack and 21 healthy controls (HCs) were enrolled. Frequencies of T cell subsets and Tregs in the peripheral blood were assessed by flow cytometry. Additionally, a model of NMOSD using purified immunoglobulin G from anti-AQP4-a

SUBMITTER: Ma X 

PROVIDER: S-EPMC8444427 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature