Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine.

ABSTRACT:

Background

Treatment-resistant depression (TRD) and pain frequently coexist clinically. Ketamine has analgesic and antidepressant effects, but few studies have evaluated individual differences in antidepressant outcomes to repeated ketamine in TRD patients with comorbid pain. Our aims were to determine the difference in ketamine's antidepressant effects in TRD patients with or without pain and then to examine whether inflammatory cytokines might contribute to ketamine's effect.

Methods

Sixty-six patients with TRD received six infusions of ketamine. Plasma levels of 19 inflammatory cytokines were assessed at baseline and post-infusion (day 13 and day 26) using the Luminex assay. Plasma inflammatory cytokines of sixty healthy controls (HCs) were also examined.

Results

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SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8444441 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature