Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease.

ABSTRACT:

Purpose

To investigate the ocular surface (OS) commensal bacteria profiles of patients with diabetes mellitus (DM) and dry eye disease (DED).

Methods

In the present study, subjects were assigned to four groups: 37 to the diabetic mellitus with dry eye disease (DM with DED) group, 22 to the diabetes mellitus (DM)-only group, 34 to the dry eye disease (DED)-only group, and 22 to the control group. Tear fluid was collected using Schirmer's tear secretion test paper. 16S ribosomal ribonucleic acid (rRNA) gene sequencing was used to analyze the bacterial microbiota.

Results

The DM with DED group showed the highest operational taxonomic unit (OTU) numbers and alpha diversity and the most different beta diversity. The groups shared the four most abundant phyla, accounting fo

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8444464 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature