Viral 3CL^pro as a Target for Antiviral Intervention Using Milk-Derived Bioactive Peptides.

ABSTRACT: Viruses of the picornavirus-like supercluster mainly achieve cleavage of polyproteins into mature proteins through viral 3-chymotrypsin proteases (3C^pro) or 3-chymotrypsin-like proteases (3CL^pro). Due to the essential role in processing viral polyproteins, 3C^pro/3CL^pro is a drug target for treating viral infections. The 3CL^pro is considered the main protease (M^pro) of coronaviruses. In the current study, the SARS-CoV-2 M^pro inhibitory activity of di- and tri-peptides (DTPs) resulted from the proteolysis of bovine milk proteins was evaluated. A set of 326 DTPs were obtained from virtual digestion of bovine milk major proteins. The resulted DTPs were screened using molecular docking. Twenty peptides (P1-P20)

SUBMITTER: Behzadipour Y 

PROVIDER: S-EPMC8444528 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature