Role of total lung stress on the progression of early COVID-19 pneumonia.

ABSTRACT:

Purpose

We investigated if the stress applied to the lung during non-invasive respiratory support may contribute to the coronavirus disease 2019 (COVID-19) progression.

Methods

Single-center, prospective, cohort study of 140 consecutive COVID-19 pneumonia patients treated in high-dependency unit with continuous positive airway pressure (n = 131) or non-invasive ventilation (n = 9). We measured quantitative lung computed tomography, esophageal pressure swings and total lung stress.

Results

Patients were divided in five subgroups based on their baseline PaO₂/FiO₂ (day 1): non-CARDS (median PaO₂/FiO₂ 361 mmHg, IQR [323-379]), mild (224 mmHg [211-249]), mild-moderate (173 mmHg [164-185]), moderate-severe (126 mmHg [114-138]) and

SUBMITTER: Coppola S 

PROVIDER: S-EPMC8444534 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature