MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of α5GABA_A receptors in aged mice.

ABSTRACT:

Background

Perioperative neurocognitive disorder (PND) is a long-term postoperative complication in elderly surgical patients. The underlying mechanism of PND is unclear, and no effective therapies are currently available. It is believed that neuroinflammation plays an important role in triggering PND. The secreted glycoprotein myeloid differentiation factor 2 (MD2) functions as an activator of the Toll-like receptor 4 (TLR4) inflammatory pathway, and α5GABA_A receptors (α5GABA_ARs) are known to play a key role in regulating inflammation-induced cognitive deficits. Thus, in this study, we aimed to investigate the role of MD2 in PND and determine whether α5GABA_ARs are involved in the function of MD2.

Methods

Eighteen-month-old C57BL/6J mice were

SUBMITTER: Zuo W 

PROVIDER: S-EPMC8444589 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature