Pathological characteristics of liver sinusoidal thrombosis in COVID-19 patients: A series of 43 cases.

ABSTRACT:

Aim

Coronavirus disease (COVID-19) is characterized by pneumonia with secondary damage to multiple organs including the liver. Liver injury (elevated alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) often correlates with disease severity in COVID-19 patients. The aim of this study is to identify pathological microthrombi in COVID-19 patient livers by correlating their morphology with liver injury, and examine hyperfibrinogenemia and von Willebrand factor (vWF) as mechanisms of their formation.

Methods

Forty-three post-mortem liver biopsy samples from COVID-19 patients were obtained from Papa Giovanni XXIII Hospital in Bergamo, Italy. Three morphological features of microthrombosis (sinusoidal erythrocyte aggregation [SEA], platelet microthrombi [PMT], and

SUBMITTER: Kondo R 

PROVIDER: S-EPMC8444906 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature