Diffusion of Protein Molecules through Microporous Nanofibrous Polyacrylonitrile Membranes.

ABSTRACT: Porous nanofibrous membranes have ultrahigh specific surface areas and could be broadly employed in protein purification, enzyme immobilization, and biosensors with enhanced selectivity, sensitivity, and efficiency. However, large biomolecules, such as proteins, have hindered diffusion behavior in the micro-porous media, significantly reducing the benefits provided by the nanofibrous membranes. The study of protein diffusion in polyacrylonitrile (PAN) nanofibrous membranes produced under varied humidity and polymer concentration of electrospinning revealed that heterogeneous structures of the nanofibrous membranes possess much smaller effective pore sizes than the measured pore sizes, which significantly affects the diffusion of large molecules through the system though sizes of proteins a

SUBMITTER: Zhao C 

PROVIDER: S-EPMC8445001 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature