Early MRI predictors of disease-free survival in locally advanced rectal cancer from the GRECCAR 4 trial.

ABSTRACT:

Background

Tailored neoadjuvant treatment of locally advanced rectal cancer (LARC) may improve outcomes. The aim of this study was to determine early MRI prognostic parameters with which to stratify neoadjuvant treatment in patients with LARC.

Methods

All patients from a prospective, phase II, multicentre randomized study (GRECCAR4; NCT01333709) were included, and underwent rectal MRI before treatment, 4 weeks after induction chemotherapy and after completion of chemoradiotherapy (CRT). Tumour volumetry, MRI tumour regression grade (mrTRG), T and N categories, circumferential resection margin (CRM) status and extramural vascular invasion identified by MRI (mrEMVI) were evaluated.

Results

A total of 133 randomized patients were analysed. Median follow-up was 41·4 (95 p

SUBMITTER: Nougaret S 

PROVIDER: S-EPMC8445107 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature