Histopathologic Characterization of Myocarditis Associated With Immune Checkpoint Inhibitor Therapy.

ABSTRACT:

Context.—

Cardiac complications of immune checkpoint inhibitor therapy are rare, but reports of myocarditis are increasing. The findings have been described in case reports as lymphocytic myocarditis, but its histopathology is underreported.

Objective.—

To review the histology of myocardial biopsy-proven cases of immune checkpoint-associated myocarditis and provide immunohistochemical characterization of the inflammatory infiltrate.

Design.—

We have encountered 6 patients with biopsy-proven myocarditis in conjunction with therapy using anti-programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) agents with and without cytotoxic T-lymphocyte associated protein 4 (CTLA-4) inhibitors and characterized the histopathology and immune cell profile.

Results.—

SUBMITTER: Sobol I 

PROVIDER: S-EPMC8445131 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature